Prof. Dr. Lang TRAN, Ph.D.

Institute of Occupational Medicine, Edinburgh, United Kingdom, EU

Specialization: Nanotoxicology and Ecotoxicology

Position: Director of Quantitative Toxicology at Institute of Occupational Medicine, Edinburgh, United Kingdom, EU

Prof. Lang Tran is a Principal Computational Toxicologist in the Statistics and Toxicology Section of the Research Division of The Institute of Occupational Medicine (IOM), where he has been working since the year 1990.

At the NANOCON 2013 conference Lang Tran will present a key-note lecture at the Session D - Health,
Safety and Environment Challenges.

Research Interests and Expertise:
Lang Tran's interests include toxicology and ecotoxicology. A researcher at the forefront of particle toxicology, Lang has been heavily involved in the evolution of Nanoparticle Toxicology as a research field. He is an Expert Consultant on the SAFEnano Initiative and is a founding member of SnIRC  ( the Safety of Nanomaterials Interdisciplinary Research Centre which has the specific remit of collecting and disseminating information and guidance on the safe use of nanomaterials and developes collaboration between IOM, the Universities of Edinburgh, Napier and Aberdeen and CSL. SnIRC brings together leading UK and international experts in particle toxicology, exposure, eco-toxicology and human studies/epidemiology to address nanoparticle risk issues.

The UK Department for International Development (DfID) commissioned the Institute of Occupational Medicine to conduct toxicological tests to determine the relative safety of the Montserrat volcanic ash. These included an inhalation experiment conducted in rats by IOM. This experiment was designed by Dr Lang Tran with the objective of testing the null hypothesis that, dose for dose, inhaled volcanic ash causes no greater pulmonary inflammation than a benchmark, low toxicity, control dust.

Relevant Publications:

  • Monteiro-Riviere, N.A., Tran, C.L. 2007. Nanotoxicology: characterization, dosing and health effects. New York: Informa.
  • Donaldson, K, Borm, P.J.A., Oberdoerster, G., Pinkerton, K.E., Stone, V., Tran, C.L. 2007. Concordance between in vitro and in vivo dosimetry in the pro-inflammatory effects of low toxicity, low solubility particles: the key role of the proximal alveolar region. Inhalation Toxicology, 20:53 – 62
  • Duffin, R., Tran, L., Brown, D., Stone, V., Donaldson, K. 2007. Pro inflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity . Inhalation Toxicology, 19: 849-856.
  • Kuempel, E.D., Tran, C.L., Castranova, V., Bailer, A.J. 2007. Response to Dr Norfeld’s letter. Letter. Inhalation Toxicology; 19: 197-198.
  • Cullen, R.T., Jones, A.D., Miller, B.G., Donaldson, K., Davis, J.M.G., Wilson, M., and Tran, C.L. 2002. Toxicity of volcanic ash from Montserrat. Institute of Occupational Medicine, Edinburgh, Report No. TM/02/01, pp. 55.
  • Tran, C.L., Buchanan, D., Cullen, R.T., Searl, A., Jones, A.D., and Donaldson, K. 2000. Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance. Inhalation Toxicol., 12, 1113-1126.